D4671
Sigma
Dermaseptin from Phyllomedusa sauvagii
≥97% (HPLC)
| Synonym: | Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln |
| CAS Number: | 136212-91-4 |
| Linear Formula: | C152H257N43O44S2 |
| Molecular Weight: | 3455.06 |
| MDL number: | MFCD00146655 |
Description
| Biochem/physiol Actions | Dermaseptin is a cationic, amphipathic antifungal peptide. Mode of action: Lysis of the cell membrane by interaction with membrane lipids. Highly potent antifungal activity at micromolar concentration. |
Properties
| assay | ≥97% (HPLC) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Mor, A., et al. Biochemistry 30, 8824, (1991) Abstract |
| Mor, A., et al., The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms. J. Biol. Chem. 269, 31635-31641, (1994) | |
| Shai, Y., Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim. Biophys. Acta 1462, 55-70 , (1999) |
